منابع مشابه
A lethal neurotoxic protein from Indian king cobra
A lethal neurotoxin protein (Toxin CM36) was isolated and purified from the Indian King Cobra (Ophiophagus hannah) venom by CM-Sephadex ion exchange chromatography and HPLC. The purified toxin had a SDSmolecular weight of 15 ± 0.5 kD. The UVabsorption spectra of Toxin CM36 showed a peak at 280 nm and an Emax at 343.8 nm, when excited at 280nm fluorescence. Toxin CM36 had an LDso of 3.5 J.lg120 ...
متن کاملA lethal neurotoxic protein from Indian king cobra (Ophiophagus hannah) venom.
A lethal neurotoxin protein (Toxin CM36) was isolated and purified from the Indian King Cobra (Ophiophagus hannah) venom by CM-Sephadex ion exchange chromatography and HPLC. The purified toxin had a SDS-molecular weight of 15 +/- 0.5 kD. The UV absorption spectra of Toxin CM36 showed a peak at 280 nm and an Emax at 343.8 nm, when excited at 280 nm fluorescence. Toxin CM36 had an LD50 of 3.5 mic...
متن کاملOhanin, a novel protein from king cobra venom, induces hypolocomotion and hyperalgesia in mice.
We have identified, purified, and determined the complete amino acid sequence of a novel protein, ohanin from Ophiophagus hannah (king cobra) venom. It is a small protein containing 107 amino acid residues with a molecular mass of 11951.47 +/- 0.67 Da as assessed by electrospray ionization-mass spectrometry. It does not show similarity to any known families of snake venom proteins and hence is ...
متن کاملHannahpep: A novel fibrinolytic peptide from the Indian King Cobra (Ophiophagus hannah) venom.
A novel fibrinolytic peptide (Hannahpep) was isolated and purified from the venom of the Indian King Cobra (Ophiophagus hannah) by thin-layer chromatography followed by reverse-phase high-performance liquid chromatography. The MW of the peptide was found to be 610 Da and the amino acid sequence of Hannahpep was determined to be Arg, His, Ala, Arg, His, Asp. Hannahpep produced defibrinogenating ...
متن کاملPurification and antibacterial activities of an L-amino acid oxidase from king cobra (Ophiophagus hannah) venom
Some constituents of snake venom have been found to display a variety of biological activities. The antibacterial property of snake venom, in particular, has gathered increasing scientific interest due to antibiotic resistance. In the present study, king cobra venom was screened against three strains of Staphylococcus aureus [including methicillin-resistant Staphylococcus aureus (MRSA)], three ...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 2007
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.2007.05268_1.x